Figure 7
Retinal function is restored in Rpe65d12/Rpe65d12 in SCID mice after human iPS cell-derived RPE transplantation. (A) Representative maximum ERG traces from treated (blue), control fellow eye (red) and wild-type mice (black). (B) Maximal b-wave peak analysis. Enhancement is calculated as the difference in maximum responses between treated and untreated control eyes. iPS-RPE-treated eyes show a 13.7-µV average difference (*p = 0.0246, n = 7). Mice receiving mitomycin-C-treated ES cells (mito-C ES) failed to show any statistically significant differences (p = 0.2853, n = 6). The value is represented as the mean ± standard error of the mean, and the p value is conducted by a ratio-paired t test.