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Figure 3 | Molecular Medicine

Figure 3

From: Morphine Induces Hyperalgesia without Involvement of µ-Opioid Receptor or Morphine-3-glucuronide

Figure 3

Pharmacodynamic results of study 2. Effect of NTX pretreatment on morphine or saline induced changes in TWL in FVB and Mrp3−/− mice. NTX pretreatment caused morphine-induced hyperalgesia in both genotypes. The combination NTX/saline had no effect on the measured latencies. Treatment effect (NTX/MOR versus NTX/saline) is shown in FVB mice (P < 0.001) and Mrp3−/− mice (P < 0.001). Strain comparison, P = 0.10. *P < 0.001 versus baseline. Values are means ± SEM. t = 0 is the time of the morphine or saline subcutaneous injection.

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