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Figure 1 | Molecular Medicine

Figure 1

From: Insulinlike Growth Factor (IGF)-1 Administration Ameliorates Disease Manifestations in a Mouse Model of Spinal and Bulbar Muscular Atrophy

Figure 1

IGF-1 increases phosphorylation of Akt and decreases AR aggregation in SBMA muscle. (A) Western blot analysis of Akt phosphorylation in skeletal muscle. Quantification of Akt, showing the mean with standard deviation. **p < 0.01 (n = 5). (B) Western blot analysis of AR protein levels in skeletal muscle. Quantification, showing the mean with standard deviation. *p < 0.05; **p < 0.01 (n = 5). (C) Immunohistochemical analysis using 1C2 antibody on cross-sections of AR97Q muscle shows a reduction of diffuse nuclear staining and nuclear inclusions in IGF-1 compared with vehicle-treated mice. Graphs, mean ± standard error of the mean (SEM); *p = 0.03. Scale bar 20 µm.

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