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Figure 2 | Molecular Medicine

Figure 2

From: Insulinlike Growth Factor (IGF)-1 Administration Ameliorates Disease Manifestations in a Mouse Model of Spinal and Bulbar Muscular Atrophy

Figure 2

IGF-1 attenuates weight loss and enhances motor behavior of SBMA mice. (A) Two mice from the same litter at wk 16 of age, showing the gross appearance of an IGF-1-treated (left) and vehicle-treated (right) SBMA mouse. (B, C) Body weight and hanging wire performance of SBMA mice treated with IGF-1 (n = 20) or vehicle (n = 20). Scale bars, SEM. (D) TreadScan assessment showed improved motor performance in AR97Q mice treated with IGF-1 (n = 6) compared with vehicle (n = 6). Scale bars, SEM. *p < 0.05; **p < 0.01. (E) Kaplan-Meier survival curves of mice treated with IGF-1 (n = 20) or vehicle (n = 20). p = 0.09, log-rank test.

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Molecular Medicine

ISSN: 1528-3658