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Figure 3 | Molecular Medicine

Figure 3

From: Insulinlike Growth Factor (IGF)-1 Administration Ameliorates Disease Manifestations in a Mouse Model of Spinal and Bulbar Muscular Atrophy

Figure 3

IGF-1 ameliorates SBMA muscle pathology. (A) Hematoxylin and eosin staining. Arrows = fibers with central nuclei; asterisks = angulated and grouped fibers. (B) Nicotinamide adenine dinucleotide staining. Asterisks = moth-eaten fibers. (C) Histograms of myofiber cross-sectional area (CSA). (D) Muscle cross-sectional area (CSA) and (E) minimal Feret diameter were increased in SBMA mice treated with IGF-1 compared with vehicle (*p × 0.05; **p < 0.01.). Transverse sections of quadriceps of 16-wk-old SBMA mice and wild-type litter-mates are shown.

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Molecular Medicine

ISSN: 1528-3658