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Figure 4 | Molecular Medicine

Figure 4

From: Insulinlike Growth Factor (IGF)-1 Administration Ameliorates Disease Manifestations in a Mouse Model of Spinal and Bulbar Muscular Atrophy

Figure 4

hrIGF-1/IGFBP3 reduces spinal cord pathology in SBMA mice. (A) Western blot of ChAT levels in spinal cord. Quantification of ChAT level, showing the mean with standard deviation, is demonstrated (*p = 0.01). (B) Nissl-stained transverse sections of ventral spinal cords of 16-wk-old mice. Quantitative analysis showed that the number of motor neurons per section is slightly increased in AR97Q mice treated with IGF-1 compared with vehicle (p = 0.09). Graphs, mean ± SEM, n = 3. (C) Western blot of Akt phosphorylation in the spinal cord. Quantification of Akt, showing the mean with standard deviation, is demonstrated (p = 1.00). (D) Western blot of AR protein levels in spinal cord of AR97Q mice. Quantification for mutant AR and of the AR aggregates, showing the mean with standard deviation, is demonstrated (p = 0.18 and p = 0.13, respectively).

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