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Figure 3 | Molecular Medicine

Figure 3

From: High Mobility Group Box 1 Contributes to the Pathogenesis of Experimental Pulmonary Hypertension via Activation of Toll-like Receptor 4

Figure 3

HMGB1 contributes to the pathogenesis of PH. Effect of chronic hypoxia (21 d) on RVSP (A) and right heart hypertrophy (B) (Fulton index; weight of RV/weight of LV + septum) in C57B16/J mice treated with aHMGB1 antibody or control IgG (50 µg every other day, IP) during hypoxia (n = 6 per group). Untreated normoxic and hypoxic C57BL6/J mice served as additional controls.

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Molecular Medicine

ISSN: 1528-3658