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Figure 6 | Molecular Medicine

Figure 6

From: High Mobility Group Box 1 Contributes to the Pathogenesis of Experimental Pulmonary Hypertension via Activation of Toll-like Receptor 4

Figure 6

TLR4 contributes to the pathogenesis of experimental PH. (A) The effect of chronic hypoxia (21 d) on TLR4 and RAGE mRNA expression in the lungs of WT mice. Data represent the mean ± SEM of four mice per group. Analysis of variance: *P < 0.05. Effect of chronic hypoxia (21 d) on RVSP (B), RV hypertrophy (C), muscularization of pulmonary arterioles (D, E) and pulmonary arteriolar wall thickness (F) in WT, Tlr4−/− and Rage−/− mice are shown. Effect of chronic hypoxia on plasma ET-1 (G) and lung ICAM levels (H) in WT, Tlr4−/− and Rage−/− mice. Data represent the mean ± SEM of six mice per group. Analysis of variance: *P < 0.05. n.s., Not significant.

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