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Figure 2 | Molecular Medicine

Figure 2

From: Bone-Targeting Endogenous Secretory Receptor for Advanced Glycation End Products Rescues Rheumatoid Arthritis

Figure 2

Biodistribution of fluorescence-labeled esRAGE, D6-esRAGE, D10-esRAGE and D14-esRAGE to bone. The fluorescence-labeled proteins were injected into mice via the tail vein at a dose of 1 mg/kg body weight. At the indicated time points, the legs, liver and kidney were dissected and sectioned. The sections were observed under a confocal laser scanning microscope to evaluate the distribution of each esRAGE at the femoral epiphysis (A), metaphysis (B), liver (C) and kidney (D). Untagged and tagged esRAGEs were distributed in bone marrow but not in articular cartilage or in growth plate. Only the tagged esRAGEs were additionally distributed and retained in the mineralized region. AC, articular cartilage; GP growth plate; scale bar = 100 µm.

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