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Table 4 Changes of expression of zebrafish proenkephalins and proopiomelanocortin in morphine-treated embryos.

From: In Vivo Regulation of the μ Opioid Receptor: Role of the Endogenous Opioid Agents

 

dre-penk a

dre-penk b

dre-pomc a

24 hpf

0.61 ± 0.12

1.32 ± 0.05a

0.90 ± 0.01

48 hpf

1.45 ± 0.06b

1.31 ± 0.10a

0.48 ± 0.15b

  1. Results represent the relative gene expression fold-changes of dre- penk a, dre-penk b and dre-pomc a in morphine-treated embryos of 24 and 48 hpf. Data shown are normalized to dr-eef1a1l1. A total of 50 embryos were used for each treatment and for each time point; the experiment was performed in triplicate and repeated four times.
  2. ap < 0.01 and bp < 0.05 (unpaired Student t test, n = 4).