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Table 4 Changes of expression of zebrafish proenkephalins and proopiomelanocortin in morphine-treated embryos.

From: In Vivo Regulation of the μ Opioid Receptor: Role of the Endogenous Opioid Agents

  dre-penk a dre-penk b dre-pomc a
24 hpf 0.61 ± 0.12 1.32 ± 0.05a 0.90 ± 0.01
48 hpf 1.45 ± 0.06b 1.31 ± 0.10a 0.48 ± 0.15b
  1. Results represent the relative gene expression fold-changes of dre- penk a, dre-penk b and dre-pomc a in morphine-treated embryos of 24 and 48 hpf. Data shown are normalized to dr-eef1a1l1. A total of 50 embryos were used for each treatment and for each time point; the experiment was performed in triplicate and repeated four times.
  2. ap < 0.01 and bp < 0.05 (unpaired Student t test, n = 4).