Figure 2

TRPV1 expression does not affect the effectiveness of MOG_35–55 immunization. (A) Proliferation following MOG_35–55 peptide restimulation of inguinal lymph node cells (n = 4 per group) from B6, TRPV1^+/− and TRPV1^−/− mice euthanized 8–10 d after immunization. (B) Proliferation following restimulation of splenocytes 16–18 d after immunization (n > 9 per group). (C) Mean stimulation index of splenocytes from naive mice stimulated with α-CD3 and α-CD28 or α-CD40 antibodies (n = 5 per group). (D–I) Production of IL-12 (D), IFN-γ (E), TNF-α (F), IL-17 (G), IL-10 (H) and IL-4 (I) by splenocytes following MOG_35–55 peptide restimulation (n > 5 per group).