Figure 5
From: TRPV1 Gates Tissue Access and Sustains Pathogenicity in Autoimmune Encephalitis
TRPV1−/− mice are protected from adoptive transfer of EAE. (A) Daily clinical scores of B6 and TRPV1−/− recipient mice following the adoptive transfer of 1 × 107 donor cells (n = 6 per group, ***p < 0.0001). (B–C) Representative H&E stained spinal cord (B) and brain (C) sections from B6 and TRPV1−/− recipient mice 24 d after transfer, original magnification 40x. (D–E) Number of B220+ and CD3+ cells within the CNS 4 d after transfer of B6 cells without (D) and with (E) injections of pertussis toxin. (F) Quantification of lymphocytes recovered from the CNS following adoptive transfer of B6 cells (n = 3 per group, *p < 0.05).