Skip to main content
Figure 3 | Molecular Medicine

Figure 3

From: XBP-1s Is Linked to Suppressed Gluconeogenesis in the Ebb Phase of Burn Injury

Figure 3

The spliced form of the transcription factor X-box-binding protein-1 (XBP-1s) is increased in the liver in the ebb phase of burn injury. Phosphorylation of hepatic IRE-1 (A) and activation of cleaved p50 ATF6 and BiP (B) were analyzed in sham and burn rats. Similar results were obtained in three independent cohorts. (C) Real-time RT PCR gene expression of the ratio of XBP-1s to XBP-1 unspliced (XBP-u) and XBP-1s target genes Dnajb9 and Pdia3 in the liver were measured in duplicate in sham and burn rats. *P < 0.05, **P < 0.01, ***P < 0.001 value for sham versus burn. Data are shown as mean ± SEM.

Back to article page