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Figure 1. | Molecular Medicine

Figure 1.

From: Dysfunction of Inflammation-Resolving Pathways Is Associated with Exaggerated Postoperative Cognitive Decline in a Rat Model of the Metabolic Syndrome

Figure 1.

Postoperative neuroinflammatory response to peripheral aseptic trauma. Aseptic surgical trauma induces binding of damage-associated molecular patterns (DAMPs) to pattern recognition receptors (PRR); this engages the innate immune system via NF-κB-dependent signaling in monocytes, to synthesize and release proinflammatory cytokines, including TNF-α, which disrupts the blood brain barrier (BBB) (6–8). Through a permeable BBB, CCR2-expressing bone marrow-derived macrophages (BM-DM) are attracted by the newly expressed chemokine MCP-1 into the brain parenchyma (5). Within the hippocampus, the activated macrophages release proinflammatory cytokines that are capable of disrupting long-term potentiation, the neurobiologic correlate of learning and memory (4,9-11).

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Molecular Medicine

ISSN: 1528-3658