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Figure 2 | Molecular Medicine

Figure 2

From: Dysfunction of Inflammation-Resolving Pathways Is Associated with Exaggerated Postoperative Cognitive Decline in a Rat Model of the Metabolic Syndrome

Figure 2

Cholinergic inflammation-resolving pathway (12–15). At its splenic nerve terminus, vagal outflow releases adrenergic agonists (rather than the usual cholinergic neurotransmitter); these catecholamines (CA) activate β2 ARs on CD3 T lymphocytes that contain choline acetyltransferase (CHAT), which is capable of synthesizing the acetylcholine needed to mediate inhibition of macrophage NF-KB activity by signaling through a7 nAChR.

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Molecular Medicine

ISSN: 1528-3658