Skip to main content
Figure 3 | Molecular Medicine

Figure 3

From: Dysfunction of Inflammation-Resolving Pathways Is Associated with Exaggerated Postoperative Cognitive Decline in a Rat Model of the Metabolic Syndrome

Figure 3

Postoperative cognitive decline is exaggerated in LCR rats coincident with time when splenic and peripheral MNCs in the LCR rats are more proinflammatory. (A) Freezing percentage in trace fear conditioning in LCR and HCR rats under sham and surgical conditions at d 3; #p < 0.05 HCR surgery versus LCR surgery. (B) TNF-α levels were higher in the media of cultured LCR splenic mononuclear cells without LPS challenge; **p < 0.01 HCR versus LCR. (C) TNF-α levels were reduced in the media of cultured HCR blood mononuclear cells stimulated with LPS (1 µmol/L); *p < 0.05 HCR sham versus LCR sham; #p < 0.05 HCR surgery versus LCR surgery at d 3. (D) TNF-α levels were decreased in the media of cultured HCR splenic mononuclear cells stimulated with LPS; **p < 0.01 HCR sham versus LCR sham; #p < 0.05 HCR surgery versus LCR surgery at d 3. Each data point represents one independent experiment. Values are means ± SD. TFC, trace fear conditioning.

Back to article page

Molecular Medicine

ISSN: 1528-3658