Figure 1

Purified wild-type and mutant recombinant ALAS2 enzymes. Shown are exon 11 predicted carboxy-terminal amino acid sequences for the ALAS2 mutations. Residues in red are novel resulting from the mutation or the frameshifts caused by the deletions. The boxed squence is a predicted helical region and the underlined sequences are identical regions in the two different frameshift mutation sequences.