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Figure 2 | Molecular Medicine

Figure 2

From: Preclinical Studies in the mdx Mouse Model of Duchenne Muscular Dystrophy with the Histone Deacetylase Inhibitor Givinostat

Figure 2

Givinostat increases the weight of mdx muscles. (A) Whole naked bodies of mdx control-untreated (CTR), TSA-treated (TSA) or givinostat-treated mice (givinostat 1 mg/kg/d = ITF1; givinostat 5mg/kg/d = ITF5; givinostat 10 mg/kg/kg = ITF10) after 105 d of treatment. (B) Graph representing the body weight of mdx mice measured as grams (g) before the treatments (time 1) and every week along the course of the treatments. Data are presented as the average ± standard error of the mean (SEM); n = 8. (C) Hind limb legs isolated from CTR-, TSA- or givinostat-treated mdx after 105 d of treatment. (D) Graph representing the quadriceps weight measured as milligrams (mg) at the end of CTR, TSA or givinostat treatment. Data are presented as the average ± SEM; n = 6. *p < 0.05; **p < 0.01.

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