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Figure 3 | Molecular Medicine

Figure 3

From: Preclinical Studies in the mdx Mouse Model of Duchenne Muscular Dystrophy with the Histone Deacetylase Inhibitor Givinostat

Figure 3

Givinostat increases the size of mdx muscles. (A) Representative images of hematoxylin and eosin staining (H&E) of tibialis anterior (TA) transverse sections of CTR-, TSA- or givinostat-treated mdx mice (givinostat 1 mg/kg/d = ITF1; givinostat 5mg/kg/d = ITF5; givinostat 10 mg/kg/kg = ITF10) at the end of the treatment. Original magnification, 10x. (B) Graph of the analysis of myofiber CSA of muscles represented in (A). Data are represented as average ± SEM; n = 6. *p < 0.05; **p < 0.01; ***p < 0.001.

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