Figure 4
Givinostat reduces fibrosis in mdx muscles. (A) Representative images of Masson trichrome staining of TA transverse sections of CTR-, TSA- or givinostat-treated mdx mice (givinostat 1 mg/kg/d = ITF1; givinostat 5 mg/kg/d = ITF5; givinostat 10 mg/kg/kg = ITF10) at the end of the treatment. Original magnification, 10x. (B) Graph representing the fibrotic index (quantification of collagen deposition) of muscles shown in (A) measured as blue area (reported as pixel2) per field. Data are presented as the average ± SEM; n = 6. ***p< 0.001.