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Figure 5 | Molecular Medicine

Figure 5

From: Preclinical Studies in the mdx Mouse Model of Duchenne Muscular Dystrophy with the Histone Deacetylase Inhibitor Givinostat

Figure 5

Givinostat reduces fat deposition in mdx muscles. (A) Representative images of oil red O staining of TA transverse sections of CTR-, TSA-, or givinostat-treated mdx mice (givinostat 1 mg/kg/d = ITF1; givinostat 5 mg/kg/d = ITF5; givinostat 10 mg/kg/kg = ITF10) at the end of the treatment. Original magnification, 10x. (B) Graph representing fat accumulation in muscles shown in (A) measured as red area (reported as pixel2) per field. Data are presented as the average ± SEM; n = 6. **p < 0.01.

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