Givinostat reduces inflammation (neutrophil granulocytes) in mdx mice. Representative images of MPO staining on TA transverse sections of CTR-, TSA-, or givinostat-treated mdx mice (givinostat 1 mg/kg/d = ITF1; givinostat 5 mg/kg/d = ITF5; givinostat 10 mg/kg/kg = ITF10). Original magnification, 10x. (B) Graph representing MPO evaluation scored as the number of MPO-positive cells per field. Data are presented as the average ± SEM; n = 6. **p < 0.01.