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Figure 8 | Molecular Medicine

Figure 8

From: Preclinical Studies in the mdx Mouse Model of Duchenne Muscular Dystrophy with the Histone Deacetylase Inhibitor Givinostat

Figure 8

Givinostat reduces Evans blue uptake in diaphragms of mdx mice. (A) Representative images of Evans blue uptake in diaphragm transverse sections of CTR-, TSA-, or givinostat-treated mdx mice (givinostat 1 mg/kg/d = ITF1; givinostat 5mg/kg/d = ITF5; givinostat 10 mg/kg/kg = ITF10). Diaphragms were harvested after a treadmill test at the end of the treatment. Original magnification, 2x. (B) Graph representing Evans blue uptake scored as red area (reported as pixel2) per field. Data are presented as the average ± SEM; n = 2. **p < 0.01.

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