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Figure 1 | Molecular Medicine

Figure 1

From: Activated Protein C Inhibits Proliferation and Tumor Necrosis Factor α-Stimulated Activation of p38, c-Jun NH2-Terminal Kinase (JNK) and Akt in Rheumatoid Synovial Fibroblasts

Figure 1

Inhibition of primary cultured human RSF proliferation by APC. (A) Effect of APC on proliferation of normal MDFs, normal HDFs and human cultured RSFs, measured using a crystal violet assay. MDFs, HDFs and RSFs were treated with 0 (control), 0.1, 1, 5 and 10 µg/mL APC. Controls were defined as 1. Values shown are mean ± SD from four (MDFs and HDFs) and three (RSFs) separate experiments. *‡#p < 0.05 versus control with the use of ANOVA followed by Bonferroni post hoc test. (B) RSFs were treated with or without TNFα (2 ng/mL) or APC (10 µg/mL), added after (third bar) or before (last bar) TNFα. Proliferation was measured by crystal violet assay. Values are shown as mean ± SD; n = 3; *p < 0.05 versus control; #p < 0.05 versus TNFα-treated RSFs, with the use of a paired t test.

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Molecular Medicine

ISSN: 1528-3658