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Figure 6 | Molecular Medicine

Figure 6

From: Enhanced Inducible Costimulator Ligand (ICOS-L) Expression on Dendritic Cells in Interleukin-10 Deficiency and Its Impact on T-Cell Subsets in Respiratory Tract Infection

Figure 6

The expression of ICOS on Th1 cells in naive and Cm-infected mice. Single spleen or lung cells were prepared from IL-10 KO and WT mice before infection (A, B) or at d 7 after Cm infection (C, D). The cells were stained on surface CD3ε, CD4 and ICOS and intracellular IFNγ. (A, C) Representative graph of flow cytometry. The cells were gated on CD3ε+CD4+ cells. (B, D) Summary of the percentage of ICOS+ and ICOS− cells within IFNγ-producing CD4+ T cells (CD3ε+CD4+ IFNγ+). Data are shown as the mean ± SD for each group (n = 4). *p < 0.05, **p < 0.01; ***p < 0.001. Representative data of three independent experiments are shown.

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