Figure 5
From: Corticotropin-releasing Factor Receptor 2 Mediates Sex-Specific Cellular Stress Responses
Lack of Crhr2−/− in female mice results in a milder ER phenotype. WT female controls show normal organelle ultrastructure (A) similar to their male littermates. When pancreatitis is induced, females, unlike their male counterparts, show milder ER ultrastructure damage in both WT (B) and Crhr2−/− (C) genotypes. (N: nucleus, RER: rough endoplasmic reticulum, ZG: zymogen granule).