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Figure 3 | Molecular Medicine

Figure 3

From: Suppression of Coronary Atherosclerosis by Helix B Surface Peptide, a Nonerythropoietic, Tissue-Protective Compound Derived from Erythropoietin

Figure 3

HBSP suppresses the formation of atherosclerotic lesions within coronary artery segments of WHHLMI rabbits. (A) HBSP reduces mean cross-sectional arterial stenosis. Left circumflex arteries were collected from WHHLMI rabbits (control, n = 7; HBSP, n = 8) and were sectioned at 500-µm intervals. The percent cross-sectional stenosis was calculated as described in Materials and Methods. The mean number of arterial segments obtained was 20.7 ± 1.4 in control animals and 16.5 ± 0.9 in animals treated with HBSP. Data are mean ± SEM; *P < 0.01. (B) HBSP reduces atheromata (that is, those causing >75% significant stenosis of the vessel lumen). On the basis of the data obtained from (A), percentage of intima with significant atheromata was calculated. Data are mean ± SEM; *P< 0.01.

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Molecular Medicine

ISSN: 1528-3658