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Figure 3 | Molecular Medicine

Figure 3

From: Carbenoxolone Blocks Endotoxin-Induced Protein Kinase R (PKR) Activation and High Mobility Group Box 1 (HMGB1) Release

Figure 3

Delayed administration of CBX rescued mice from lethal sepsis. BALB/c mice were subjected to lethal sepsis (induced by CLP), and intraperitoneally administered with saline (0.2 mL/mouse) or CBX at indicated doses at +24, +48 and +72 h after CLP. Animal survival rates were monitored for 2 wks, and the Kaplan-Meier method was used to compare the differences between groups. *P < 0.05 versus saline control group.

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Molecular Medicine

ISSN: 1528-3658