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Figure 4 | Molecular Medicine

Figure 4

From: Carbenoxolone Blocks Endotoxin-Induced Protein Kinase R (PKR) Activation and High Mobility Group Box 1 (HMGB1) Release

Figure 4

CBX attenuated sepsis-induced HMGB1 accumulation. BALB/c mice were subjected to sepsis by CLP and administered with control saline (0.2 mL/mouse) or CBX (6.0 mg/kg) at 24 and 48 h CLP At 50 h after CLP the levels of HMGB1 and various cytokines in the serum (Panel A,B) and peritoneal lavage fluid (Panel C) were determined by cytokine antibody arrays (Panel A) and Western blotting analysis (Panel B, C), respectively. The relative HMGB1 levels were expressed as mean ± SD of two independent experiments (n = 2) in arbitrary units. *P< 0.05 versus saline group (+ CLP).

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