Antiangiogenic and Antitumoral Effects Mediated by a Vascular Endothelial Growth Factor Receptor 1 (VEGFR-1)-Targeted DNAzyme

Table 3 Effect of DT18 on biochemical parameters in mice.

	Alanine aminotransferase	Aspartate aminotransferase	Blood urea nitrogen	Serum creatinine
Saline	52.37 ± 23.96	120.17 ± 17.35	6.8 ± 1.0	26.96 ± 15.64
INV-Ctrl	30.73 ± 3.31	116.55 ± 30.94	6.64 ± 0.99	50.78 ± 43.17
DT18	54.22 ± 22.2	138.08 ± 26.06	7.08 ± 0.94	52.77 ± 43.8
F value	1.443	0.863	0.232	0.765
P value	0.292	0.454	0.796	0.478

Data were analyzed by one-way ANOVA followed by the Dunnett test. The DT18 group was compared with the saline group and INV-Ctrl group (n = 5).

ISSN: 1528-3658