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Table 6 Determination of DT18 pharmacokinetics in mice.

From: Antiangiogenic and Antitumoral Effects Mediated by a Vascular Endothelial Growth Factor Receptor 1 (VEGFR-1)-Targeted DNAzyme

 

DT18 PK parameters

Dose (mg/kg)

T1/2α (h)

T1/2β (h)

Cmax(mg/mL)

AUC (mg/mL h)

Vd (mL/kg)

10

0.1

46.7

84.4

97

890

  1. The two-compartmental model of intravenous bolus injection best fit the plasma concentration-time curve. T1/2α, distribution half-life; T1/2β, elimination half-life; Cmax, maximum concentration; AUC, area under the curve; Vd, volume of distribution.