Skip to main content
Figure 1 | Molecular Medicine

Figure 1

From: Emerging Role of High-Mobility Group Box 1 (HMGB1) in Liver Diseases

Figure 1

Structure and function of the HMGB1 protein. (A) HMGB1 is composed of the A box, B box and C tail domains. (B) As a DNA chaperone, nuclear HMGB1 participates in DNA replication, recombination, transcription and repair. In particular, HMGB1 interacts with and enhances the activities of a number of transcription factors, including p53, p73, the retinoblastoma protein (RB), members of the Rel/NF-κB family and estrogen receptor (ER). (C) Once released, HMGB1 binds to various receptors to activate DAMP signaling involved in multiple cellular processes. (D) Cytoplasmic HMGB1 protein binds with beclin 1 to induce autophagy. (E) Membrane HMGB1 promotes neurite outgrowth and platelet activation.

Back to article page