Table 1 HMGB1-targeting therapeutic strategies.
From: Emerging Role of High-Mobility Group Box 1 (HMGB1) in Liver Diseases
Therapeutic strategies | Mechanism of action | References |
|---|---|---|
HMGB1-neutralizing antibody | Â | Â |
Mouse anti-HMGB1 DPH1.1 antibody | Inhibition of HMGB1 activity | 99 |
Mouse anti-HMGB1 2G7 antibody | Inhibition of HMGB1 activity | 100 |
Anti-HMGB1 chicken IgY polyclonal antibody | Inhibition of HMGB1 activity | 101 |
A box protein | Inhibition of HMGB1 activity | 10 |
RNA interference | Â | Â |
HMGB1 siRNA | Suppression of HMGB1 expression | 102 |
HMGB1 shRNA | Suppression of HMGB1 expression | 103 |
Adsorption | Inhibition of HMGB1 activity | 104 |
Chemicals | Â | Â |
Molecular hydrogen | Inhibition of HMGB1 release | 105 |
Quercetin | Inhibition of HMGB1 release | 106 |
Atorvastatin | Suppression of HMGB1 expression | 107 |
Tanshinone II A | Suppression of HMGB1 expression | 108 |
Dexamethasone | Inhibition of HMGB1 release | 109 |
Gold sodium thiomalate | Inhibition of HMGB1 release | 109 |
Chloroquine | Inhibition of HMGB1 release | 110 |
Ethyl pyruvate | Inhibition of HMGB1 release | 111 |
Glycyrrhizin | Inhibition of HMGB1 activity and release | 112 |
Stearoyl lysophosphatidylcholine | Inhibition of HMGB1 release | 113 |
Chinese medicinal herbs | Â | Â |
Danggui (Angelica sinensis) | Inhibition of HMGB1 release | 114 |
Danshen (Salvia miltiorrhiza) | Inhibition of HMGB1 release | 115 |
Green tea (Camellia sinensis) | Inhibition of HMGB1 release and activity | 116,117 |
Mung bean (Vigna radiata) | Inhibition of HMGB1 release | 118 |
HMGB1 receptor and signaling pathway inhibition | Â | Â |
sRAGE | Inhibition of HMGB1-RAGE pathway | 119 |
Other | Â | Â |
Anticoagulant agents (for example, thrombomodulin) | Inhibition of HMGB1 activity | 101 |
Endogenous hormones (for example, insulin) | Inhibition of HMGB1 release | 120 |
Vagus nerve stimulation (for example, nicotine) | Inhibition of HMGB1 release | 121 |