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Table 2 Flow analysis of apoptosis in dacomitinib-treated cells.

From: Evaluation of the Antitumor Activity of Dacomitinib in Models of Human Bladder Cancer

 

UM-UC-6

UM-UC-9

Gated cells

Dac

DMSO

Sts

Dac

DMSO

Sts

% Viable

3

64.7

2.4

35.2

66.2

27.9

% Apoptotic

73

22.1

56

8.8

7.9

17.7

% Necrotic

24

13.2

41.6

56

25.9

54.4

  1. UM-UC-6 and UM-UC-9 cells were analyzed by flow cytometry following a single 48-h treatment of 2 µmol/L dacomitinib (Dac) or equivalent concentration of DMSO. Resulting percentage of gated cells is indicated. Dac induced apoptosis in UM-UC-6, but not in UM-UC-9 cells compared with DMSO treatment. The percentage of necrotic cells increased in both cell lines; 0.5 µmol/L staurosporin (Sts) was used as positive control for apoptosis (p < 0.0001).