Table 3 Immunohistochemical analysis of biomarkers expression in UM-UC-6 xenografts.
From: Evaluation of the Antitumor Activity of Dacomitinib in Models of Human Bladder Cancer
Group | Mitosis/HPF | p-EGFR | p-ERK | E-cad | Ki67 | EGFR | HER2 | p-Akt |
|---|---|---|---|---|---|---|---|---|
V1 | 6–7 | absent | 10–20 | >90 | 90 | 100 | 35–40 | 40 |
V2 | 5–7 | 30 | 10–20 | >90 | 80–90 | 100 | 65–70 | 70 |
V3 | 5–7 | 20 | 10–20 | >90 | 80–90 | 100 | 65–70 | 80 |
E1 | 1 | absent | <10 | 50 | 75–80 | 90 | 25–30 | 80 |
E2 | 0–1 | absent | absent | 10–20 | 65–70 | 90 | 45–50 | 70 |
E3 | 0–1 | absent | <10 | 20–30 | 60–65 | 100 | 75–80 | 80 |
L1 | 1–2 | absent | absent | >90 | 60–65 | 100 | 65–70 | 80 |
L2 | 1–2 | absent | <10 | >90 | 65–70 | 100 | 75–80 | 90 |
L3 | 2–3 | absent | <10 | 10–20 | 70–75 | 100 | 60–65 | 80 |