Nerve fibers involved | ARA 290 (n = 21) | Placebo (n = 17) | |||
---|---|---|---|---|---|
Variable | Change | Number of patients (%) | Change | Number of patients (%) | |
Cold detection threshold | Aδ and C | Decrease | 19 (91) | Decrease | 11 (65) |
Warm detection threshold | Aδ and C | Decrease | 17 (81) | Decrease | 13 (77) |
Increase | 1 (5) | ||||
Thermal sensory limen | Aδ and C | Decrease | 4 (19) | Decrease | 4 (24) |
Increase | 2 (10) | ||||
Paradoxical heat sensation | Aδ | Decrease | 8 (38) | Decrease | 7 (41) |
Cold pain threshold | Aδ and C | Increase | 3 (14) | — | 0 |
Heat pain threshold | C | Decrease | 3 (14) | Decrease | 1 (6) |
Increase | 5 (24) | ||||
Mechanical detection threshold | Aβ | Decrease | 11 (52) | Decrease | 10 (59) |
Mechanical pain threshold | Aβ | Decrease | 11 (52) | Decrease | 4 (24) |
Increase | 4 (19) | Increase | 2 (12) | ||
Mechanical pain sensitivity | Aβ + C | Decrease | 2 (10) | Decrease | 1 (6) |
Increase | 5 (24) | ||||
Dynamic mechanical allodynia | Aβ | Increase | 11 (52) | Increase | 3 (18) |
Windup ratio | Aδ and C | Increase | 4 (19) | Increase | 2 (12) |
Vibration detection threshold | Aβ | Decrease | 20 (95) | Decrease | 15 (88) |
Pressure pain threshold | Aδ and C | Decrease | 3 (14) | Decrease | 1 (6) |
Increase | 10 (48) | Increase | 7 (41) |