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Table 2 Results of baseline QST.

From: ARA 290 Improves Symptoms in Patients with Sarcoidosis-Associated Small Nerve Fiber Loss and Increases Corneal Nerve Fiber Density

 

Nerve fibers involved

ARA 290 (n = 21)

Placebo (n = 17)

Variable

Change

Number of patients (%)

Change

Number of patients (%)

Cold detection threshold

Aδ and C

Decrease

19 (91)

Decrease

11 (65)

Warm detection threshold

Aδ and C

Decrease

17 (81)

Decrease

13 (77)

  

Increase

1 (5)

  

Thermal sensory limen

Aδ and C

Decrease

4 (19)

Decrease

4 (24)

  

Increase

2 (10)

  

Paradoxical heat sensation

Decrease

8 (38)

Decrease

7 (41)

Cold pain threshold

Aδ and C

Increase

3 (14)

0

Heat pain threshold

C

Decrease

3 (14)

Decrease

1 (6)

  

Increase

5 (24)

  

Mechanical detection threshold

Decrease

11 (52)

Decrease

10 (59)

Mechanical pain threshold

Decrease

11 (52)

Decrease

4 (24)

  

Increase

4 (19)

Increase

2 (12)

Mechanical pain sensitivity

Aβ + C

Decrease

2 (10)

Decrease

1 (6)

  

Increase

5 (24)

  

Dynamic mechanical allodynia

Increase

11 (52)

Increase

3 (18)

Windup ratio

Aδ and C

Increase

4 (19)

Increase

2 (12)

Vibration detection threshold

Decrease

20 (95)

Decrease

15 (88)

Pressure pain threshold

Aδ and C

Decrease

3 (14)

Decrease

1 (6)

  

Increase

10 (48)

Increase

7 (41)

  1. Patients in the ARA 290 and placebo groups showed functional impairment of both small nerve fibers (Aδ and C) as well as larger sensory nerve fibers (Aβ). Data are expressed as number of patients deviating beyond the 95% confidence interval of a sex- and age-matched normal population. Test sites of face, hand and foot are pooled for calculation of percentages. “Decrease” indicates a loss of function; “Increase” indicates a gain in function compared with a normal population. For example, a decreased CDT means that a patient required a lower temperature stimulus than normal to determine that an object was cold (that is, a decrease in sensitivity).