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Figure 4 | Molecular Medicine

Figure 4

From: Binge Alcohol Consumption Aggravates Oxidative Stress and Promotes Pathogenesis of NASH from Obesity-Induced Simple Steatosis

Figure 4

Serum TG, hepatic TG, expression of PPAR-γ mRNA and TNF-α mRNA in the liver tissue of OLETF and OLET untreated rats and rats treated with ethanol. All data are mean ± SD of 10 rats in each group. (A) Serum TG. *P = 0.0001, OLETF untreated versus OLET untreated rats. (B) Hepatic TG levels. *P = 0.00001, OLETF untreated versus OLET untreated rats. (C) Expression of PPAR-γ mRNA in the liver. *P < 0.001, OLETF untreated versus OLET untreated rats. In both OLETF and OLET rats, PPAR-γ mRNA was not altered after treatment with ethanol compared with their untreated controls. (D) Expression of TNF-α mRNA in the liver. *P = 0.0005, OLETF untreated versus OLET untreated rats. TNF-α mRNA was significantly increased in all groups of OLETF rats treated with ethanol compared with OLETF untreated rats.

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Molecular Medicine

ISSN: 1528-3658