Counterbalancing forces of adaptive immunity in the atherosclerotic plaque: proinflammatory Th1 cells and atheroprotective Treg cells, as proposed in a review article (43). We have since learned that native rather than oxidized LDL serves as a T-cell antigen. Reproduced from (43):
Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N. Engl. J. Med. 2005;352(16): 1685–95. Copyright © 2005 Massachusetts Medical Society. Reprinted with permission.