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Table 1 Mg deficiency during pregnancy alters maternal and fetal hepatic fatty acid profiles.

From: Maternal Magnesium Deficiency in Mice Leads to Maternal Metabolic Dysfunction and Altered Lipid Metabolism with Fetal Growth Restriction

 

Maternal

Fetal

 

Control

Mg deficient

Control

Mg deficient

FA (mg per 100 mg liver)

14:0

0.36 ± 0.22

0.74 ± 0.13**

1.75 ± 0.21

1.55 ± 0.19

16:0

30.2 ± 0.86

30.8 ± 2.55

27.8 ± 1.00

26.3 ± 0.58*

16:1

2.02 ± 0.34

3.63 ± 1.02**

5.21 ± 0.30

4.74 ± 0.68

18:0

4.46 ± 0.48

4.8 ± 0.82

7.89 ± 0.87

8.75 ± 0.94

18:1n-7

2.70 ± 0.25

3.01 ± 0.59

3.90 ± 0.23

3.37 ± 0.38*

18:1n-9

30.3 ± 2.54

34.7 ± 2.68**

38.1 ± 1.60

32.8 ± 2.48**

18:2n-6

24.2 ± 2.74

19.3 ± 4.96*

13.8 ± 1.90

19.4 ± 2.62***

18:3n-6

0.97 ± 0.18

0.48 ± 0.58*

0.36 ± 0.36

0.78 ± 0.35*

18:3n-3

0.54 ± 0.37

0.37 ± 0.99*

0.23 ± 0.34

0.87 ± 0.46*

20:4n-6

2.80 ± 0.57

1.24 ± 0.44***

0.26 ± 0.27

0.71 ± 0.33*

22:6n-3

1.41 ± 0.42

0.19 ± 0.33***

0.67 ± 0.05

0.93 ± 0.17*

Percentage of total

MUFA

37.0 ± 1.20

39.8 ± 3.06*

47.0 ± 1.80

40.1 ± 3.56**

SFA

33.0 ± 2.70

40.0 ± 3.20**

37.4 ± 1.80

37.1 ± 1.73

PUFA

30.0 ± 2.96

20.2 ± 6.07**

15.6 ± 2.67

22.8 ± 4.17**

Ratio

PUFA:SFA

0.86 ± 0.10

0.63 ± 0.23*

0.33 ± 0.16

0.61 ± 0.24**

n-3:n-6 FA

0.07 ± 0.01

0.06 ± 0.01*

0.06 ± 0.02

0.09 ± 0.01*

Activity

Desaturation indexa

1.00 ± 0.08

1.14 ± 0.09*

1.26 ± 0.07

1.12 ± 0.1*

ELOVL6b

1.15 ± 0.09

1.29 ± 0.06*

1.65 ± 0.04

1.58 ± 0.09

  1. Values are means ± SD; n = 8–9 per group.
  2. aTotal desaturation index = (16:1n-7 + 18:1n-7 + 18:1n-9)/(14:0 + 16:0 + 18:0).
  3. bELOVL6 (elongase 6) activity index = (18:0 + 18:1n-9)/16:0.
  4. *P < 0.05, **P < 0.01, ***P < 0.0001 versus control.