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Figure 10 | Molecular Medicine

Figure 10

From: Brain Region-Specific Alterations in the Gene Expression of Cytokines, Immune Cell Markers and Cholinergic System Components during Peripheral Endotoxin-Induced Inflammation

Figure 10

Lethal inflammation results in brain region-specific decreases in Chrm1 mRNA expression. Mice were injected with LPS (8 mg/kg, IP) or saline and euthanized 4 h later. Brain regions were isolated and processed for Chrm1 mRNA expression analysis by qPCR, as described in Materials and Methods. Data are shown as mean ± SEM (n = 15 mice per group); ***P < 0.002. Because of limited RNA levels in the hippocampus, hypothalamus, striatum and thalamus, three tissue samples (from the same region and treatment group) were combined before RNA extraction; therefore, n = 5 was used for statistical analysis in these regions. No Chrm1 mRNA was detected in the cerebellum of LPS-treated mice.

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