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Figure 4 | Molecular Medicine

Figure 4

From: RETRACTED ARTICLE: High Systemic Levels of the Cytokine-Inducing HMGB1 Isoform Secreted in Severe Macrophage Activation Syndrome

Figure 4

Longitudinal serum analyses before and after introduction of etoposide treatment in patient 3. Serum concentration of total HMGB1 and hyperacetylated HMGB1 are demonstrated in (A) with the different HMGB1 redox-forms illustrated in (B). The expression of serum levels of HMGB1 as well as (C) ferritin and (D) IFN-γ corresponded very well to the clinical course of MAS with a rapid decline and clinical improvement after etoposide treatment. IL-18 and MCP-1 levels were increased during critical disease with a prolonged release period (E,F). CsA: cyclosporine A; MP-pulses: methylprednisolone pulses.

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Molecular Medicine

ISSN: 1528-3658