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Figure 5 | Molecular Medicine

Figure 5

From: RETRACTED ARTICLE: High Systemic Levels of the Cytokine-Inducing HMGB1 Isoform Secreted in Severe Macrophage Activation Syndrome

Figure 5

Serum analyses in patient 4 before and after treatment with etoposide. Serum concentration of total HMGB1 and hyperacetylated HMGB1 are presented in (A) with the different HMGB1 redox-forms illustrated in (B). Two serum samples were analyzed where normalized levels of (A) HMGB1, (C) ferritin and (D) IFN-γ were documented after intervention with etoposide and subsequent clinical improvement. IL-18 declined but was still elevated (E) while MCP-1 increased (F). MP-pulses: methylprednisolone pulses.

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Molecular Medicine

ISSN: 1528-3658