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Table 2 Extracellular HMGB1 in clinically relevant modes of cell death.

From: RETRACTED ARTICLE: High Systemic Levels of the Cytokine-Inducing HMGB1 Isoform Secreted in Severe Macrophage Activation Syndrome

 

Apoptosis

Necrosis

Pyroptosis

Immunoreactivity

Noninflammatory

Proinflammatory

Proinflammatory

Redox isoform

Sulfonyl HMGB1

Fully reduced or disulfide HMGB1

Disulfide HMGB1

NLS sites

Hypoacetylated

Hypoacetylated

Hyperacetylated

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Molecular Medicine

ISSN: 1528-3658