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Figure 5 | Molecular Medicine

Figure 5

From: Downregulation of miRNAs during Delayed Wound Healing in Diabetes: Role of Dicer

Figure 5

Network analysis among the predicted miRNA regulators and wound-healing genes. Regulators of the wound-healing genes altered in a diabetic rat wound (compared with normal rat wound, d 7 postwounding) were identified using the experimentally validated ChEA tool within ENRICHR. These were mapped onto the predicted targets of the 19 miRNAs altered (from Targetscan V. 7.0) in the same tissues. A total of 28 regulators were identified as potential miRNA targets, and networks of these prioritized regulators with the altered wound-healing genes were drawn using Cytoscape and a numerical value of 1.0. The green nodes are the miRNA-targeted regulators, and the yellow nodes are the altered wound-healing genes.

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