Figure 3
Peripherally-evoked responses of wide-dynamic range units. (A) Application of phasic brush, press, pinch, and (B) Von Frey filaments applied to cutaneous receptive fields of WDR neurons evoked single-unit firing activity in diabetic animals. Viral-mediated knockdown of NAV1.3 attenuated the responsiveness of diabetic WDR neurons (*p < 0.05; n = 16 cells/group). (C) A representative peristimulus histogram shows the peripherally evoked response of WDR single units to phasic brush (PB), compressive press (144 g/mm2), and pinch (538 g/mm2). Graphs are mean ± SEM.