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Table 2 Associations between blood pressure and miR-181a level in serum and the kidney.a

From: Signatures of miR-181a on the Renal Transcriptome and Blood Pressure

  

Systolic blood pressure

  

Diastolic blood pressure

 
 

Model Ab

Model Bc

Model Cd

Model De

Model A

Model B

Model C

Model D

Serum log10 renin (pg/mL)

4.2 ± 1.8 P = 0.020

7.8 ± 2.3 P = 0.001

10.2 ± 3.0 P = 0.001

4.5 ± 2.4 P = 0.067

2.0 ± 1.2 P = 0.098

4.2 ± 1.5 P = 0.004

5.3 ± 2.2 P = 0.018

NS

Kidney miR-181a (dCt)

−1.8 ± 0.9 P = 0.041

NS

−3.0 ± 1.2 P = 0.016

−2.7 ± 0.8 P = 0.002

−1.5 ± 0.6 P = 0.010

NS

−1.9 ± 0.9 P = 0.042

−1.5 ± 0.7 P = 0.038

Serumf miR-181a (dCt)

−1.7 ± 0.5 P = 0.002

NS

−2.4 ± 0.8 P = 0.002

−1.5 ± 0.6 P = 0.009

−1.7 ± 0.3 P < 0.001

−1.1 ± 0.4 P = 0.015

−2.5 ± 0.5 P < 0.001

−2.0 ± 0.4 P < 0.001

Serumg miR-181a (dCt)

−1.7 ± 0.5 P = 0.002

NS

−2.5 ± 0.7 P = 0.001

−1.9 ± 0.5 P = 0.001

−1.8 ± 0.3 P < 0.001

−1.1 ± 0.4 P = 0.010

-2.5 ± 0.5 P < 0.001

−2.0 ± 0.4 P < 0.001

  1. P, level of statistical significance; NS, not significant.
  2. aData are expressed as β-coefficients (with standard errors and P values) from linear regression models in which clinic blood pressure (BP) was the dependent variable and log10-transformed serum levels of renin or delta cycle thresholds (dCt) (inverse measure of miR-181 expression) as one of the independent variables.
  3. bModel A: all subjects with available clinical and molecular data and measured clinic BP.
  4. cModel B: all subjects with BP transformed using the therapy-adjustment algorithm.
  5. dModel C: subjects who were not on antihypertensive medication.
  6. eModel D: subjects who were not on antihypertensive medication and had a clinic SBP ≤ 140 mmHg and DBP ≤ 90 mmHg.
  7. fSerum model without serum levels of renin.
  8. gSerum model adjusted for log10 circulating levels of renin included.