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Figure 4 | Molecular Medicine

Figure 4

From: Galantamine Attenuates Type 1 Diabetes and Inhibits Anti-Insulin Antibodies in Nonobese Diabetic Mice

Figure 4

Galantamine delays the onset of hyperglycemia and diabetes. The 1 mg/kg galantamine (n = 11) or saline (n = 10) was administered intraperitoneally daily to NOD mice beginning at 5 wks of age. Blood glucose levels were measured weekly, with two successive weeks of blood glucose >199 mg/dL, indicating onset of diabetes. Administration of galantamine (A) significantly reduced the average blood glucose over time (p < 0.05, two-way ANOVA), and (B) significantly delayed onset of diabetes (p < 0.05, Mantel-Cox, results of two combined experiments).

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