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Figure 2 | Molecular Medicine

Figure 2

From: Transgenic Expression of miR-222 Disrupts Intestinal Epithelial Regeneration by Targeting Multiple Genes Including Frizzled-7

Figure 2

miR-222 inhibits growth of small intestinal mucosa. (A) Body weights in littermates and miR222-Tg mice. Values are the mean ± SEM (n = 10). (B) Gastrointestinal gross morphology. (C) Photomicrographs of the small intestine. Scale bar: 50 µm. (D) Changes in the length of villi (left), crypt (middle) and villus:crypt ratio (n = 6). *P < 0.05 compared with littermates. (E) Proliferating cells in small intestinal crypts as measured by BrdU labeling (1 h postinjection, green). (F) Immunoblots of PCNA and CDK4 in the mucosa.

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