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Figure 6 | Molecular Medicine

Figure 6

From: Aspirin’s Active Metabolite Salicylic Acid Targets High Mobility Group Box 1 to Modulate Inflammatory Responses

Figure 6

Schematic representation of SA’s mechanisms of suppression of HMGB1’s proinflammatory activities. Extracellular HMGB1 is recognized by two different receptors, CXCR4 and TLR4 (16). The fully reduced HMGB1 induces CXCR4-mediated cell migration. SA inhibits cell migration induced by HMGB1. The disulfide HMGB1 induces TLR4-mediated activation of the NF-κB signaling pathway (16,17), resulting in transcriptional activation of genes coding for COX-2 (PTGS2) and proinflammatory cytokines (IL6 and TNF). SA suppresses disulfide HMGB1-induced PTGS2, IL6 and TNF expression.

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Molecular Medicine

ISSN: 1528-3658