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Figure 3 | Molecular Medicine

Figure 3

From: AMP-Activated Protein Kinase and Glycogen Synthase Kinase 3β Modulate the Severity of Sepsis-induced Lung injury

Figure 3

Metformin diminishes the severity of ALI in mice subjected to hemorrhage and CLP-induced sepsis. (A) Images show lung sections of control (sham), CLP- or hemorrhage/CLP- or metformin and hemorrhage/CLP-treated mice. Bars: 100 µm. Arrows indicate spaces filled with a mixed mononuclear/neutrophilic infiltrate, cellular debris and proteinaceous material. Alveolar walls are also thickened, and the septa are edematous. (B) Metformin increased survival rates following hemorrhage and CLP. (C) Decrease of pulmonary edema and lung permeability was evidenced by measurement of lung wet-to-dry ratios and BAL proteins in mice treated with metformin and hemorrhage/CLP, as compared with hemorrhage/CLP group. Panels (D), (E) and (F) show amounts of BAL TNF-α, MIP-2, KC, IL-6 or HMGB1 in sham, hemorrhage/CLP- or metformin and hemorrhage/CLP-treated mice (means ± SD (n = 5 mice/group), *p < 0.05, **p < 0.01).

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